The primary aim is to facilitate an overall well-being for patients suffering from incurable neurological disorders through Neuroregenerative Rehabilitative Therapy (NRRT). In addition to the above, providing support to cellular therapy research & regenerative medicine and increasing awareness about its applications are supplementary objectives.
In the past donated organs were transplanted to replace the diseased or failed organs in the recipients. Soon the number of recipients exceeded the number of donated. To overcome this demand, cell therapy offered the possibility of replacement of the damaged cells of tissue with new cells. Stem cell infusion helps to treat a plethora of conditions including cerebral palsy, spinal cord injury, intellectual disability, and other neurodegenerative syndromes as well.
Stem cells have the potential to develop into different cells of the tissues (of the body) and the ability of self-renewal. When serving as a repair system, the stem cells divide without limit as long as the person is alive. As they divide, they remain as stem cells or develop into cells with more specialized functions, like a brain cell or a muscle cell.
Stem cells, from different sources, have three common properties: They can grow into specialized cell types such as nerve cells, muscle cells, and blood cells.
Impairments linked to neuromuscular conditions are usually irreversible due to inadequate cell regeneration or impaired cells in the central nervous system. It was observed that the cellular characteristics of autologous stem cells had the capability of treating major neurological disorders without incurring any side effects. With their neurotrophic properties, self-renewal & differentiation capacity, and immune modulation effects, the bone marrow-derived stem cells are considered as a promising candidate for treating disorders related to the nervous system.
For cell treatment, bone marrow derived mesenchymal stem cells are isolated from the marrow tissue (extracted from the patient’s hip bone) in an expedited, painless and safe way. By centrifugation procedure, a sufficient number of stem cells are separated from the unwanted tissue within a few hours. These injectable stem cells are infused intrathecally into the spinal area or the damaged muscle points, as per the need of the patients.
These bone marrow-derived stem cells have many useful properties that lead to great clinical improvement in post-cell-based therapy. According to various clinical trials, treatment with bone marrow derived mesenchymal stem cells have shown improvement in patients with traumatic brain injury, spinal cord injury and other neurological disorders through axonal sprouting and remyelination, potential to replace/protect the damaged neurons/cells, and neovascularization.
How do the infused stem cells act? Once infused into the body,
– The infused stem cells journey toward the nervous system and blend into the neural circuits to mend or improve the disrupted synaptic transmission.
– Post infusion, improved neuropathological condition, upregulated Aß clearance and reduced deposition is detected within a short period.
– The infused stem cells reduce neuroinflammation and provide protective immunomodulatory effect.
– The stem cells secrete neurotrophic influence and nerve growth factors, bringing cognitive and memory improvement in patients.
Apart from encouraging effects, renewed brain plasticity is also observed in patients following intrathecal delivery of stem cells. With the new medical breakthrough in stem cell therapy, the treatment has become a highly sought-after curative. To know about the treatment efficacy, one must understand the efficiency of stem cells in terms of engraftment, migration, cytokines and growth factors. However, cell-based therapy is a promising contribution to regenerative medicine and has gained considerable clinical attention. Read extra details on NeuroGen BSI.
Knowing the Specialists: Managing all aspects of a child’s unique diagnosis is essential for successful comprehensive treatment. Well-rounded treatment approaches require a team of multidisciplinary specialists, usually with a pediatrician at the center of the group. Pediatricians are generalists who manage the treatment plan, recognize specific issues and recommend specialists who can treat those issues. Each specialist uses ongoing treatment and assessments to ensure that all areas of the child’s development are proceeding as normally as possible. Scoliosis (spinal curvature) and shortened achilles tendons are some specific movement and posture issues that are treated with physical therapy. Physical therapy is an important prevention measure, as these issues can get worse over time. Proper treatment of the above conditions can also improve the chance of a child walking independently.
A few tricks to help your child with autism: Create a home safety zone. Carve out a private space in your home where your child can relax, feel secure, and be safe. This will involve organizing and setting boundaries in ways your child can understand. Visual cues can be helpful (colored tape marking areas that are off limits, labeling items in the house with pictures). You may also need to safety proof the house, particularly if your child is prone to tantrums or other self-injurious behaviors. Connecting with a child with ASD can be challenging, but you don’t need to talk-or even touch-in order to communicate and bond. You communicate by the way you look at your child, by the tone of your voice, your body language – and possibly the way you touch your child. Your child is also communicating with you, even if he or she never speaks. You just need to learn the language.
Supports and repairs cells: Everything we do is based on our cells. The way we act is affected by cellular health. Cellular problems create latency; By feeding them well, they can become much more energetic and efficient. Relax! Remember the last time you spent a whole day in a crowded shop or amusement park. You were probably exhausted when you got home. The brain of people with autism can feel that chaos and exhaustion all the time. By understanding how your child’s brain works and taking the right measures, you will make your and your child’s world easier to manage. Enter the world of your child! Look for the hidden reasons for the child’s behaviors. Odd or provocative behaviors are usually a sign that something is not perceived correctly.
Stem Cells: So far, umbilical cord blood has been successfully used in the treatment of over 75 conditions, such as various types of cancer, blood disease and immune deficiencies, such as leukemia, sickle cell anemia (siclemia), thalassemia, Hodgkin’s disease and non-Hodgkin’s lymphoma. Stem cells also treat very rare, potentially fatal conditions, such as Krabbe’s disease or Sanfilippo’s syndrome. But from year to year new diseases appear on the list of 75 that can be treated with the help of stem cells.
Dr Alok Sharma is a renowned and respected Neurosurgeon, Neuroscientist and Professor across the world in medicine with an extensive surgical expertise & experience in the areas of Neurosurgery, Neuroscience and Stem cells. In 1995, Dr Alok Sharma held a place at the Karolinska hospital in Stockholm Sweden where neural transplantation was done for the first time ever in the world. In 1998, Dr Alok Sharma was placed at the University of Colorado health sciences center in Denver, USA where the world’s first randomized trial for cell transplantation was done for Parkinson’s disease. Dr Alok Sharma obtained his MBBS, M.S. and M.Ch. from the Seth G.S. Medical College & KEM Hospital of Mumbai University. Subsequently, Dr Alok Sharma did fellowships in two departments that were first to do neural transplantation. Read more info Dr Alok Sharma.