Category: General Health

Professional critical care nurse responsibilities guides with Tene Kishan Los Angeles? Tene Kishan Los Angeles, California has a background in health care and public administration. She earned 3 college degrees and has a Bachelor’s of Arts Degree in political science, a Bachelor’s of Science in nursing and a Master’s Degree in public administration. Tene Kishan is Registered Nurse with a background in ICU/Critical Care and owns a non-profit organization that’s provides services and puts on community events for youth in need of housing services in the area of Los Angeles County.

Choosing the right major is always an important step when researching how to become a registered nurse in the icu. When we researched the most common majors for a registered nurse in the icu, we found that they most commonly earn bachelor’s degree degrees or associate degree degrees. Other degrees that we often see on registered nurse in the icu resumes include master’s degree degrees or diploma degrees. You may find that experience in other jobs will help you become a registered nurse in the icu. In fact, many registered nurse in the icu jobs require experience in a role such as registered nurse. Meanwhile, many registered nurse in the icus also have previous career experience in roles such as staff nurse or licensed practical nurse.

Tene Kishan about ICU nurse careers: Because of the challenges and responsibility that come with operating in an ICU, hospitals require various certifications that guarantee they are hiring the best quality nurses. Many nurses who want to advance their careers are now turning to certifications. Additionally, certifications are a great way to increase ICU nurse salaries. Four certifications specifically constitute nursing in critical care conditions: CRRN (Adult) – Nurses with this certification can provide adequate care for critically ill adult patients. With this certification, you can work in general ICUs, surgical ICUs, trauma units, transport and flight operations, and cardiac care units. CCRN (Adult) – This specialty certification is for nurses who provide direct care to acutely/critically ill adult patients.

Critical care nurses provide highly skilled, expert care for the most severely ill or injured patients. This introduction – part one of a six-part series – provides an overview of their role. Critical care nurses provide expert, specialist care to the most severely ill or injured patients in intensive care units and the wider hospital. They are highly trained and skilled safety-critical professionals working as part of a multidisciplinary team. Critical care is classified using four levels of patient acuity, as outlined in Table 1. Updated guidelines for the provision of intensive care services (Faculty of Intensive Care Medicine, 2019) recommend that level-3 patients should have a minimum registered nurse–patient ratio of 1:1 and level-2 patients must have a minimum nurse–patient ratio of 1:2.

Duties and Responsibility of ICU nurse: Critical care nurses may also care for pre-and post-operative patients when those patients require ICU care. Besides, some act as managers and policymakers, while others perform administrative duties. Assess patients’ pain levels and sedation requirements. Prioritize nursing care for assigned critically ill patients based on assessment data and identified needs. Assess family adaptation levels and coping skills to determine whether intervention is needed. Acting as a patient advocate. Providing education and support to patient families. ICU nurses must be able to draw ABG Blood and interpret the report correctly. ICU nurses should have enough knowledge about GCS (Glasgow Coma Scale) and also the evaluation capacity of patient condition. Discover even more details on Tene Kishan.

Reconstructive transplantation research and science from Karim Sarhane today? We performed a study with rodents and primates that showed this new delivery method provided steady release of IGF-1 at the target nerve for up to 6 weeks,” Dr. Karim Sarhane reported. Compared to animals without this hormone treatment, IGF-1 treated animals (rodents and primates) that were injected every 6 weeks showed a 30% increase in nerve recovery. This has the potential to be a very meaningful therapy for patients with nerve injuries. Not only do these results show increased nerve recovery but receiving a treatment every 6 weeks is much easier on a patient’s lifestyle than current available regiments that require daily treatment.

During his research time at Johns Hopkins, Dr. Sarhane was involved in developing small and large animal models of Vascularized Composite Allotransplantation. He was also instrumental in building The Peripheral Nerve Research Program of the department, which has been very productive since then. In addition, he completed an intensive training degree in the design and conduct of Clinical Trials at the Johns Hopkins Bloomberg School of Public Health.

The combination of nanoparticle carriers with hydrogels as a hybrid delivery system has recently come into favor for purposes including passively controlled drug release, stimuli-responsive drug delivery, site-specific drug delivery, and detoxification. The addition of a hydrogel to a nanoparticle delivery system allows for an added level of tunability as well as increased assurance that the nanoparticles remain at the local site of delivery in vivo (Gao et al., 2016; Norouzi et al., 2016). A promising approach being pursued by our group for repair of PNI involves encapsulation of IGF-1 into nanoparticles that provide sustained release of IGF-1 for over 6 weeks. The nanoparticles are then suspended within a biomimetic nanofiber hydrogel composite carrier to facilitate in vivo application and preliminary results have been encouraging (Santos et al., 2016). The approach involves injection of the composite hydrogel into the denervated target muscle and around the nerve distal to the site of injury, such that the released bioactive IGF-1 diffuses through the target tissues. Our unpublished data suggests that IGF-1 does not act on regenerating axons in gradient-dependent fashion, as uniform delivery along the distal nerve results in a robust treatment effect. However, the question of gradient dependence has not been specifically addressed to our knowledge and warrants further investigation. To achieve maximal treatment effect, IGF-1 will likely need to be delivered for the duration of the regenerative period, which can last many months or even years. It is unlikely that an engineered drug delivery system will be developed that can achieve this duration of release with a single dose. We therefore anticipate that interval ultrasound-guided reinjections will be needed, with the dosing schedule being dependent on the duration of drug release.

Effects with sustained IGF-1 delivery (Karim Sarhane research) : Functional recovery following peripheral nerve injury is limited by progressive atrophy of denervated muscle and Schwann cells (SCs) that occurs during the long regenerative period prior to end-organ reinnervation. Insulin-like growth factor 1 (IGF-1) is a potent mitogen with well-described trophic and anti-apoptotic effects on neurons, myocytes, and SCs. Achieving sustained, targeted delivery of small protein therapeutics remains a challenge.

Insulin-like growth factor-1 (IGF-1) is a particularly promising candidate for clinical translation because it has the potential to address the need for improved nerve regeneration while simultaneously acting on denervated muscle to limit denervation-induced atrophy. However, like other growth factors, IGF-1 has a short half-life of 5 min, relatively low molecular weight (7.6 kDa), and high water-solubility: all of which present significant obstacles to therapeutic delivery in a clinically practical fashion (Gold et al., 1995; Lee et al., 2003; Wood et al., 2009). Here, we present a comprehensive review of the literature describing the trophic effects of IGF-1 on neurons, myocytes, and SCs. We then critically evaluate the various therapeutic modalities used to upregulate endogenous IGF-1 or deliver exogenous IGF-1 in translational models of PNI, with a special emphasis on emerging bioengineered drug delivery systems. Lastly, we analyze the optimal dosage ranges identified for each mechanism of IGF-1 with the goal of further elucidating a model for future clinical translation.

Insulin-like growth factor-1 (IGF-1) is a particularly promising candidate for clinical translation because it has the potential to address the need for improved nerve regeneration while simultaneously acting on denervated muscle to limit denervation-induced atrophy. However, like other growth factors, IGF-1 has a short half-life of 5 min, relatively low molecular weight (7.6 kDa), and high water-solubility: all of which present significant obstacles to therapeutic delivery in a clinically practical fashion (Gold et al., 1995; Lee et al., 2003; Wood et al., 2009). Here, we present a comprehensive review of the literature describing the trophic effects of IGF-1 on neurons, myocytes, and SCs. We then critically evaluate the various therapeutic modalities used to upregulate endogenous IGF-1 or deliver exogenous IGF-1 in translational models of PNI, with a special emphasis on emerging bioengineered drug delivery systems. Lastly, we analyze the optimal dosage ranges identified for each mechanism of IGF-1 with the goal of further elucidating a model for future clinical translation.

Peripheral nerve regeneration studies by Karim Sarhane right now? Insulin-like growth factor 1 (IGF-1) is a hormone produced by the body that has the potential to be used as a treatment for nerve injuries. IGF-1 may help heal nerve injuries by decreasing inflammation and buildup of damaging products. Additionally, it may speed up nerve healing and reduce the effects of muscle weakness from the injury. However, a safe, effective, and practical way is needed to get IGF-1 to the injured nerve.

Dr. Sarhane is published in top-ranked bioengineering, neuroscience, and surgery journals. He holds a patent for a novel Nanofiber Nerve Wrap that he developed with his colleagues at the Johns Hopkins Institute for NanoBioTechnology and the Johns Hopkins Department of Neuroscience (US Patent # 10500305, December 2019). He is the recipient of many research grants and research awards, including the Best Basic Science Paper at the Johns Hopkins Residents Research Symposium, the Basic Science Research Grant Prize from the American Foundation for Surgery of the Hand, the Research Pilot Grant Prize from the Plastic Surgery Foundation, and a Scholarship Award from the American College of Surgeons. He has authored to date 46 peer-reviewed articles, 11 book chapters, 45 peer-reviewed abstracts, and has 28 national presentations. He is an elected member of the Plastic Surgery Research Council, the American Society for Reconstructive Microsurgery, the American Society for Reconstructive Transplantation, and the American Society for Peripheral Nerves.

Gene delivery targeted to skeletal myocytes has also demonstrated promise as a method of upregulating IGF-1 production in PNI models (Flint et al., 2004; Rabinovsky and Draghia-Akli, 2004; Nagata et al., 2014; Tsai et al., 2016). This approach has been applied both systemically as well as directly to the local site of PNI. Amongst the gene delivery protocols included in Table 2, the work of Nagata et al. (2014) is notable given its use of a biocompatible polyplex nanomicelle as a means of delivering IGF-1 plasmid DNA (pDNA) to the local site of PNI (Nagata et al., 2014). The diverse strategies employed by these systemic GH axis modifiers demonstrate the flexibility with which IGF-1 can potentially be incorporated into future translational approaches. However, these systemic therapeutic approaches are all limited by the resulting systemic upregulation of IGF-1 with the associated risks and side effects as well as the lack of fine control of IGF-1 levels within the target tissues, specifically the injured nerve and denervated muscle.

Recovery by sustained IGF-1 delivery (Karim Sarhane research) : To realize the therapeutic potential of IGF-1 treatment for PNIs, we designed, optimized, and characterized a novel local delivery system for small proteins using a new FNP-based encapsulation method that offers favorable encapsulation efficiency with retained bioactivity and a sustained release profile for over 3 weeks. The IGF-1 NPs demonstrated favorable in vivo release kinetics with high local loading levels of IGF-1 within target muscle and nerve tissue.

Research efforts to improve PNI outcomes have primarily focused on isolated processes, including the acceleration of intrinsic axonal outgrowth and maintenance of the distal regenerative environment. In order to maximize functional recovery, a multifaceted therapeutic approach that both limits the damaging effects of denervation atrophy on muscle and SCs and accelerates axonal regeneration is needed. A number of promising potential therapies have been under investigation for PNI. Many such experimental therapies are growth factors including glial cell line-derived neurotrophic factor (GDNF), fibroblast growth factor (FGF), and brain-derived neurotrophic growth factor (Fex Svenningsen and Kanje, 1996; Lee et al., 2007; Gordon, 2009). Tacrolimus (FK506), delivered either systemically or locally, has also shown promise in a number of studies (Konofaos and Terzis, 2013; Davis et al., 2019; Tajdaran et al., 2019).

The positive trophic and anti-apoptotic effects of IGF-1 are primarily mediated via the PI3K-Akt and MAP-kinase pathways (Ho and 2007 GH Deficiency Consensus Workshop Participants, 2007; Chang et al., 2017). Autophosphorylation of the intracellular domain of IGF-1 receptors results in the activation of insulin receptor substrates 1–4, followed by activation of Ras GTPase, and then the successive triggering of Raf, MEK, and lastly ERK. Through activation of Bcl-2, ERK has been shown to prevent apoptosis and foster neurite growth. Ras activation also triggers aPKC and Akt (Homs et al., 2014), with the active form of the latter inhibiting GSK-3ß and thus inhibiting a number of pro-apoptotic pathways (Kanje et al., 1988; Schumacher et al., 1993; Chang et al., 2017). Additionally, the JAK-STAT pathway is an important contributor toward the stimulation of neuronal outgrowth and survival by facilitating Growth Hormone (GH) receptor binding on target tissue to induce IGF-1 release (Meghani et al., 1993; Cheng et al., 1996; Seki et al., 2010; Chang et al., 2017). These biochemical mechanisms enable GH and IGF-1 to exert anabolic and anti-apoptotic effects on neurons, SCs, and myocytes (Tuffaha et al., 2016b).

Clean room class factory in China? This specification is designed to set important national guidelines and policies, unify construction acceptance requirements, unify testing strategies, and ensure project high quality, save more energy, protect the environment and safe operation during the construction of clean rooms (including prefabricated clean rooms, the same below). This specification is applicable to the construction and acceptance of newly-built and reconstructed industrial clean rooms and general biological clean rooms, and is not applicable to the construction and acceptance of special biological clean rooms with biological safety requirements. Find more information on clean room class.

The clean room must be created according to the design plans. If the design needs to be changed during construction, there shall be a change notice from the design unit. Construction and acceptance cannot be carried out without drawings and technical requirements. Before the construction of the clean room, a detailed construction scheme and procedures shall be formulated. During the construction, all types of work shall cooperate closely and construct according to the procedures. The type of work constructed first shall not hinder the subsequent construction.

The clean room workshop is also called the dust free workshop, gmp cleanroom, the industrial clean room (Clean Room) and the dust free room. It refers to the removal of pollutants such as particles, harmful air and bacteria in the air within a certain space, and the indoor temperature,cleanliness, indoor pressure, air velocity and air distribution, noise and vibration, lighting and static control. A specially designed clean room for a particular requirement. That is to say, no matter how the extemal air conditions change, the clean room can maintain the characteristics of cleanliness temperature and humidity and pressure.

The main materials, equipment, finished products and semi-finished products used in the project shall comply with the design regulations, and shall be provided with factory certificate or quality appraisal certificate. When there is doubt about the quality, it must be inspected. Expired materials shall not be used.

As long as you want the clean room project, Suzhou Pharma Machinery Co., Ltd. will realize it for you. Choose a reliable engineering company, Suzhou Pharma Machinery Co., Ltd., will be responsible for your project to the end, and the reputation is guaranteed. Our company has completed 500+ clean room projects all over the world. Many new and old customers like to buy the products they want in our company. The price is reasonable, the integrity is guaranteed, and the after-sales service is good.

During the construction of the clean room, the intermediate inspection and acceptance shall be carried out after the construction of each process, and the records shall be put on record. In addition to this specification, the construction and acceptance of the clean room shall also comply with the provisions of the current relevant national standards.The architectural decoration construction of the clean room shall be carried out after the completion of the roof waterproof works and the external enclosure structure, the installation of the external doors and windows, and the acceptance of the main structure.

For the air outlet equipped with similar diffuser, the air volume can be found out according to the air volume resistance curve of diffuser (factory air volume resistance curve or field measured air volume resistance curve) and the measured diffuser resistance (the difference between the static pressure in the orifice and the indoor pressure). When measuring, use a micro manometer and a fine pitot tube, or use a fine rubber tube to replace the pitot tube, but the plane of the measuring hole must be parallel to the air flow direction. In addition, other methods approved by the professional testing department can also be used.

Its contents include the indoor decoration works, the installation of doors and windows, the gap sealing, as well as the sealing of the joints between various pipelines, lighting lamps, purification Suzhou Pharma is one of the leading turnkey project providers for pharmaceutical, food, herbal, cosmetic, electronics factory and chemical plants. We offer projects as per GMP regulations. As being pioneers in this field, the solutions from Suzhou Pharma is readily accepted by the customers.

The clean room is generally made of foam color steel or rock wool board with a vertical wall and an independent air-conditioning air supply system. The air is filtered through high-efficiency three-stage filtration in junior high schools. The personnel and materials are equipped with an air shower room and a transfer window for clean filtration.

Airflow is the most important factor in controlling cleanliness and temperature and humidity, and it also has some influence on noise. Therefore, the wind speed measurement is the first step in the clean room test. The purpose of the wind speed measurement is to confirm that the air flow sent by the filter meets the design specifications, and the second is to confirm the uniformity of the air flow. In some occasions, due to site restrictions, the indoor ventilation volume must also be converted by multiplying the wind speed by the outlet area. Discover additional info on https://www.sz-pharma.com/.

Excellent peripheral nerve regeneration research studies with Karim Sarhane? Dr. Karim Sarhane is an MD MSc graduate from the American University of Beirut. Following graduation, he completed a 1-year internship in the Department of Surgery at AUB. He then joined the Reconstructive Transplantation Program of the Department of Plastic and Reconstructive Surgery at Johns Hopkins University for a 2-year research fellowship. He then completed a residency in the Department of Surgery at the University of Toledo (2021). In July 2021, he started his plastic surgery training at Vanderbilt University Medical Center. He is a Diplomate of the American Board of Surgery (2021).

Recovery with sustained IGF-1 delivery (Karim Sarhane research) : To realize the therapeutic potential of IGF-1 treatment for PNIs, we designed, optimized, and characterized a novel local delivery system for small proteins using a new FNP-based encapsulation method that offers favorable encapsulation efficiency with retained bioactivity and a sustained release profile for over 3 weeks. The IGF-1 NPs demonstrated favorable in vivo release kinetics with high local loading levels of IGF-1 within target muscle and nerve tissue.

One-fifth to one-third of patients with traumatic injuries to their arms and legs experience nerve injury, which can be devastating. It can result in muscle weakness or numbness, prevent walking or using the arms, and reduce the ability to perform daily activities. Even with surgery, some nerve injuries never recover, and currently there are not many medical options to address this problem. In 2022, the researchers plan to perform this research on more primates to triple the size of the original group. The study can then move into phase I clinical trials for humans.

The amount of time that elapses between initial nerve injury and end-organ reinnervation has consistently been shown to be the most important predictor of functional recovery following PNI (Scheib and Hoke, 2013), with proximal injuries and delayed repairs resulting in worse outcomes (Carlson et al., 1996; Tuffaha et al., 2016b). This is primarily due to denervation-induced atrophy of muscle and Schwann cells (SCs) (Fu and Gordon, 1995). Find extra details on Karim Sarhane.

Beauty detox guides by NatalieMochinsBeautyBlog? Splashes of ice cold water on the face every morning and night results in brighter, smoother and firmer skin. I have been doing this for five years and it’s a winner. The only tip that I use daily is that when applying serums, I wait and take a couple minutes in between each one of my skincare steps to allow them to properly sink in. I swear by using pure lanolin products or a tub of simple Vaseline. You can get a big tub for a reasonable price at your local chemist and it works for many things – I use it for cuts, cracked nipples after breastfeeding and of course for my lips as a nourishing overnight treatment. Discover even more details at best hair curling tool for long hair.

Apply eye shadow on the folds of the eyes, using two colors, the darker one is applied on the base of the fold and the lighter one on top, make sure to blend it and use color that would accentuate the eyes and compliment her over-all look. Then apply blush on to the cheeks using upward motion to put color on the cheeks, blend it in with the foundation so that the make up will be seamless. Then apply lip liner and lipstick, the shade should tie up the desired over-all look. For a pouty lip, apply lipstick from the center to the sides, add a lip shiner to enhance the lip color.

Impossibly tired, she didn’t have time to put on makeup. So if you fall asleep at night with makeup on your face, the result is not good at all. Clogged pores of the skin can lead to acne or black spots or blemishes. Follow the skin care routine after removing makeup from the face. And here’s how to do it right. After removing the makeup, clean the face with cleanser or face wash. Exfoliation of the skin is a very important part. Exfoliation is needed to remove and deep cleanse the dead skin cells. You can use face scrub once or twice a week. Good quality toner is needed for oily skin. The use of this toner is very important to maintain the pH balance of the skin and to shorten the pores of the skin. After cleansing and exfoliation, some dirt remains on the skin, toner is used to remove them.

Hot and humid weather can trigger those annoying rashes, sunburns, breakouts. The best way to avoid these problems is to adapt your skin care routine to suit the summer weather conditions. The temperature is rising and if you look closely your skin must be screaming for extra attention. Heavy creams and textures of winters can lead to clogged pores and cause further skin problems and therefore you need to adapt your skin regimen according to the environment and the weather. Invest in a good eye gel, and a sun protection lip balm for adequate protection. Apply sunscreen on your feet and don’t forget to exfoliate and moisturize them.

Exfoliation is an important step in your daily skin routine, more so if you want to keep it healthy and young looking. Microdermabrasion facial which is one of the methods of exfoliation, not only does it rid your skin of all the dead skin cells, but it also regulates blood flow to all over the face, which enables your skin to retain its soft texture. You can make your natural scrub at home by mixing walnut-shell powder with yoghurt to gently exfoliate your skin. In addition to this, the antioxidants present in walnut will also help remove excess dirt while also promoting a naturally radiant skin.

Whether your bedroom is on a busy street, or you can’t sleep in total silence, a noisemaker is a great bedtime tool for “rocking” yourself to sleep. Both white and pink noise have may help improve sleep quality. Also, if you’re a new parent in desperate need of a night’s rest, they’re beneficial for getting babies to sleep through the night as well. A home air purifier is a great way to maintain a healthy appearance. For the best results, consider going with a modern high-efficiency particulate air (HEPA) air purifier. By protecting your skin from poor ventilation—by way of pollution coming in from the outdoors, as well as indoor irritants—you limit the free-flowing particulate matter from penetrating your skin. This helps slow the aging process, improves skin tone, reduces redness and dryness, and helps with blemish-prone skin.

What Are Essential Oils? Typically created through the process of distillation — which separates the oil and water-based compounds of a plant by steaming — they are highly concentrated oils that have a strong aroma. In fact, sometimes they are called volatile aromatic oils because of their high concentration of the aromatic compounds. They also are simply called aromatherapy oils. How do essential oils work? By concentrating the oils of these plants, you are literally separating the most powerful healing compounds of a plant into a single oil. For instance, in order to get one single 15ml bottle of rose essential oil, it take 65 pounds of rose petals! These therapeutic oils in plants protect the plant from insects, shield the plant from a harsh environment and help them adapt to their surroundings. By taking essential oils, you are harnessing the protective and beneficial powers of a plant. Read more information at nataliemochinsbeautyblog.com.

Tene Kishan high quality critical care nurse duties guides? Duties and Responsibility of ICU nurse: Critical care nurses may also care for pre-and post-operative patients when those patients require ICU care. Besides, some act as managers and policymakers, while others perform administrative duties. Assess patients’ pain levels and sedation requirements. Prioritize nursing care for assigned critically ill patients based on assessment data and identified needs. Assess family adaptation levels and coping skills to determine whether intervention is needed. Acting as a patient advocate. Providing education and support to patient families. ICU nurses must be able to draw ABG Blood and interpret the report correctly. ICU nurses should have enough knowledge about GCS (Glasgow Coma Scale) and also the evaluation capacity of patient condition.

Tene Kishan has a background in health care and public administration. She earned 3 college degrees and has a Bachelor’s of Arts Degree in political science, a Bachelor’s of Science in nursing and a Master’s Degree in public administration. Tene Kishan is Registered Nurse with a background in ICU/Critical Care and owns a non-profit organization that’s provides services and puts on community events for youth in need of housing services in the area of Los Angeles County.

Tene Kishan on ICU nurse careers: The first step to becoming an ICU nurse is to be a registered nurse (RN). Before you become a registered nurse, you have to graduate with a BSN or an ADN from an accredited nursing program. Afterward, you must pass the NCLEX examination. There are bridge programs that allow you to advance your education level in less time. One example is the ADN to BSN program. To become a more attractive candidate you may consider obtaining an advanced degree like an MSN. There are bridge programs to help cut down on time on school. There are programs such as the BSN to MSN and RN to MSN (if you are already a licensed RN). You will need at least two years of nursing experience in a position specializing in intensive care nursing to become an ICU nurse.

To deliver highly skilled care, critical care nurses undertake postgraduate study and ongoing training. The Step Competency Framework underpins critical care nurse education; it recognises that, to be able to deliver high-quality care to patients, staff need the knowledge and skills so they can work at the highest level, with standardisation across all critical care units. Step 1 for adult critical care begins when a nurse with no previous experience of the specialty starts working in intensive care medicine. Steps 2 and 3 should be incorporated into academic intensive care programmes. Find even more info at Tene Kishan.

High quality clean cannabis oil products 2022? How can marinee pass through a blood brain barrier, leading to tumor cell apoptosis? In fact, in the treatment of cancer, the special effects of cannabinoids should be placed under the spotlight, and is remembered by the world. US “Immunization Biology” was published in August 2010 “Cannabin induced immune cell apoptosis as an immunosuppressive pathway”, it has been reviewed in detail of cannabinoid treatment cancer. Cannabin is a group of compounds present in cannabis sativa L., to regulate their physiological and behavioral effects by activating specific cannabin receptors. As the cannabin receptor (CB1 and CB2) and endogenous cannabinoid systems, the study of cannabinoids were expanded in an exponential level. Cannabin has been proven to be an effective immunosuppressive agent and anti-inflammatory agent, and has shown in various immune-mediated diseases (such as multiple sclerosis, diabetes, infectious shock, rheumatoid arthritis and allergic asthma) ) Intermediary guidance. Cannabin Receptor 1 (CB1) is mainly expressed in cells of the central nervous system and peripheral cells. In contrast, cannabin receptor 2 (CB2) is mainly expressed in immune cells. The exact mechanism of cannabinoid mediated immunosuppression is now just being understood, and can be roughly divided into four ways: cell apoptosis, proliferation inhibition, cytokine and chemokinetic factor, and T regulate cells (T REGS) Induction. This article focuses on natural and synthetic cannabinoids by activating CB2 receptor induced apoptosis, focusing on the apoptosis mechanism of cannabin-mediated immunosuppression on different immune cell populations, and discusses the activation of CB2 Inflammation and autoimmune diseases and immune systems provide a new treatment, without poor psychotropic effects. See additional info at Rick Simpson oil lung cancer.

How to use RSO oil(cannabis oil)? Sublingually: It’s the fastest form of absorption. You put a drop under the tongue and hold it for a minute or two. It usually takes the average person about 90 days to ingest the full 60 gram or 60 ml RSO oil treatment. I suggest that people start with three doses per day, about the size of half a grain of short-grained dry rice. The patient should take this dosage every 8 hours, early in the morning, then again in the afternoon, and then they should take their final dose of the day, about an hour before bedtime. It should also be noted that as a patient begins to ingest this oil, the patient does not normally feel the RSO oil’s effects until about an hour after they have taken their dosage, so please be aware of this fact. A beginner’s dose such as I am describing would equal about 1/4 of a drop.

The best light intensity for plant growth during flowering: Plant growth rate increases up to PAR (PPFD) levels of 1,500 µmols/m2/sec at optimum temperature and atmospheric levels of CO2. We recommend a PAR level of 750 µmols/m2/sec for your grow room. Increasing PAR above this level does not increase the growth rate enough to justify the additional energy consumed. The PAR levels (PPFD) vs Photosynthesis (Growth Rate) for Cannabis Sativa at 30 Degrees Celcius and normal atmospheric CO2 levels.

Tommy Chong on battling rectal cancer by using cannabis oil. Currently, 18 states have legalized the recreational use of marijuana and 36 states have legalized the medicinal use of cannabis. Many cancer patients (16-24%) use cannabis oil to curtail symptoms related to cancer or cancer treatment. Dr. Newcomb, the first author of the publication, stated that “cannabis has some important properties that motivate cancer patients to use it for nausea and vomiting, appetite, pain, fatigue.” Previous studies indicate that cannabis is widely used among cancer patients with late-stage disease or with other poor mental or physical health states. Due to improvements in early detection and cancer treatments, the number of cancer survivors will expand by one million per year, which includes at least 150,000 colorectal cancer (CRC) patients. Therefore, about 2.7 to 4 million survivors may intentionally use cannabis for symptom management or other reasons. Presently, cannabis use and its side effects are not monitored among cancer patients and survivors. The Newcomb Group, from the Division of Public Health Sciences, evaluated the demographic, behavioral, and clinical characteristics of cannabis use among colorectal cancer patients from Washington State. CRC has a high prevalence and several treatments with side effects thus, CRC provides a good model for understanding cannabis use among men and women with cancer. This study is published in Cancer Causes & Control.

There are three species of cannabis: Sativa, Indica, and Ruderalis. Hemp has been used for thousands of years and its usability is unlike anything else. It can be used for oil for cooking and converting to fuel. The seeds, which are one of the most nutritional seeds on the planet, supply nearly every mineral and vitamin the body needs. It can be used for clothing and, not only requires half the amount of water to turn into fiber as cotton, but also requires no chemicals or fertilizers. It can also be used as housing insulation, fiber boards, and its excellent phytoremediation which is a plant that can remove toxins, radiation, and contamination from water and soil. Hemp was actually used in the agricultural fields around the Chernobyl nuclear disaster site, in order to help remove the heavy metals and radiation from the unusable land. Scientists, behind the plant, used Hemp as phytoremediation, also stated that as well as being excellent for the job of removing harmful waste, the Hemp could then be converted to bio-diesel afterward. Now, the conversion to bio-diesel is far from environmentally friendly, but the fact this plant has the ability to do this is incredible.

After going through the unsuccessful surgery, he had decided to try something different. For almost a year Rick Simpson indulged himself in extracting the oil from the cannabis plant and ingested that oil orally. Although he had been taking the cannabis oil for other health issues, the cancer diagnosis reminded him something, almost 30 years earlier he heard a radio ad which stated that “The University of Virginia had found that cannabinoid in cannabis through THC could kill cancer in mice.” From there he figured out that if this oil can kill cancer in mice there is a possibility that cannabis oil would kill his cancer too. Discover more details on https://www.rsocancerfree.com/.

Bitters recipe sugar curbing and diet tricks by MyTrendingStories.com? We’re about to blow your mind with all the things you can freeze!! Be prepared to look at your freezer in awe. But first, let us give you three crazy simple reasons you should use your freezer with purpose and intention… Go ahead and just become BFFs with your freezer already! Because when we’re done with you, you’ll never want to part ways with it again. And you may just find that you’re using it more than you used to Saves You Money – The number one reason to freeze food is the fact that it saves you buckets of money. You can buy food in bulk and freeze whatever you won’t use right away, which means you can take advantage of allllll the sales. (As long as it fits within your grocery budget, of course!)

My Trending Stories diet guides: Dietary supplements are wildly popular. About 114 million Americans — roughly half the adult population — take at least one supplement, running up a collective tab of over $28 billion in 2010 alone. It’s easy to see why supplements are such big sellers. The public has a legitimate desire for good health, and the supplement industry has a strong desire for good sales. Medications are regulated by the FDA. Before a prescription or over-the-counter drug can be sold in the United States, the manufacturer must submit data supporting its safety and efficacy, and after the medication is approved, the FDA continues to monitor adverse reactions. Even with all these safeguards, problems still occur, prompting the FDA to withdraw many medications and to require strong warning labels on others.

How Does Advanced Keto Work? This BHB-supplement helps your system attain ketosis faster. This is the state where fat is converted into ketones and these are then burnt for energy. BHB, as you know, is the last product produced in your body before your system enters ketosis. You can achieve ketosis by cutting out carbs from your diet or by taking a BHB supplement like Advanced Keto. Needless to say, this supplement, containing full-spectrum BHB salts, allows you to reach ketosis in the easiest way possible by flushing your system with BHB to attain ketosis faster to lose weight. Why is Keto is the go-to diet for weight loss? This is because it works! It works by cutting out carbs from your diet almost completely. It forces your body to go into a state of ketosis, a metabolic state in which your liver burns fats instead of carbs to produce energy. This causes fat loss and weight loss, both. How does this supplement work? Instant fat burn: Keto Advanced helps the body by releasing stored fats. It does so by burning fat for energy in place of carbohydrates. This miracle product can help individuals to lose almost 5 pounds of weight by just using it for one week.Accelerated fat burn: Using this product for even a very short period of time can bring about a drastic change in weight. Keto Advanced containing BHB leads to accelerated fat burn and a weight loss of up to 20 pounds can be expected during the first month of its use.Transform your body: Taking Keto Advanced for 3 to 5 months after the achievement of weight loss goal can help in stabilizing diet. Moreover, it can also help individuals in maintaining and transforming their new, slim body.

My Trending Stories nutrition tricks: Bitter orange extract: Bitter orange extract is found in citrus fruits such as Seville oranges and contains synephrine, a stimulant with effects similar to ephedrine, according to a 2012 study. Because of this, the makers of bitter orange extract patches claim it can help to lose weight by helping to burn more calories and fat, as well as by suppressing appetite. However, the study concluded that these effects are minimal and further research is still needed. Ashwagandha: Ashwagandha is an ancient herb that has been shown to potentially help alleviate stress and anxiety, which can lead to mindless eating, or “stress eating,” says Dr. Seltzer. While studies have shown that it can reduce levels of cortisol (a.k.a. the stress hormone), this isn’t a guarantee that it’ll help you drop pounds. Read extra details at Mytrendingstories scam. Group groove is the best choice for anyone of any age who wants to have fun and sweat a ton. For those fitness enthusiasts who find the exercise a bit routine and boring, this group groove is for you. You will have a fun way to get a great cardio workout with a smile on your face. You will never stop tapping your foot or wiggling your hips whenever you hear choreographed songs. And your dancing muscles will be stretched out and you will stay and feel young again!

Leave a little extra room for liquids: You can also freeze soups, sauces and stews in airtight containers. Liquids expand so you’ll want to fill freezer bags and containers only three-quarters of the way, so they don’t explode. Freeze fruits and vegetables: Freezing seasonal fruits and veggies is great, especially this time of year. Freezing your fresh garden veggies now will allow you to use them all year long. Same with in-season fruits, which are sweeter and perfect to add to your smoothies. Casseroles can be frozen either cooked or uncooked, but it’s a bit better to freeze uncooked or partially cooked casseroles as opposed to freezing fully cooked casseroles. Submerge the bag in cold water and change the water out every 30 minutes. A 1-pound package can thaw in 1 hour or less where a 3 to 4-pound package may take several hours. Food thawed with this method should be cooked immediately and not refrozen. Microwave thawing: Cook food immediately after being thawed in the microwave. Keeping food partially cooked after using the microwave to thaw can pose as a food safety hazard. If you have more questions about freezing and food safety, check out the USDA website. For other tips on staying healthy and well, visit bannerhealth.com.

Individuals who have a low risk of coronary heart disease are unlikely to require medical assessment ahead of starting an exercise regimen. However, prior medical evaluation may be advisable for some people, including those with diabetes. Anyone who is unsure about safe levels of exercise should speak to a healthcare professional. It is possible to consume hundreds of calories a day by drinking sugar-sweetened soda, tea, juice, or alcohol. These are known as “empty calories” because they provide extra energy content without offering any nutritional benefits. Unless a person is consuming a smoothie to replace a meal, they should aim to stick to water or unsweetened tea and coffee. Adding a splash of fresh lemon or orange to water can provide flavor. Avoid mistaking dehydration for hunger. An individual can often satisfy feelings of hunger between scheduled meal times with a drink of water.

Medical news in 2022? Self-monitoring is a critical factor in successfully losing weight. People can use a paper diary, mobile app, or dedicated website to record every item of food that they consume each day. They can also measure their progress by recording their weight on a weekly basis. Those who can track their success in small increments and identify physical changes are much more likely to stick to a weight loss regimen. People can also keep track of their body mass index (BMI) using a BMI calculator. See additional details at https://mytrendingstories.com/article/barley-malt-extracts-health-benefits. Slowly Build Core Muscles: Focus on slowly building up your core muscles, rather than rushing into things. Here are 3 of our favorite core strengthening moves: Leg circles, Scissor kick, Plank leg lift. If you’re looking for a quick and easy move, start with leg circles. Simply lay on your back, with your arms at your side and palms facing towards the ground. Next, bend your left knee, and plant your left foot on the floor. Finally, extend your right leg into the air and draw a circle. Reverse the circle, going back and forth in different directions. After about ten circles, switch legs.

Despite the media attention and all the information that’s available, people simply aren’t losing weight. But there are some very good reasons for this: too much misinformation is available, too many people rely on fad diets, too many people look for a pill to help them lose weight and too many people just don’t want to acknowledge that it takes some work to lose the weight. Yet for those who do work to lose weight, the end result is always worth it. It’s important to make the right kind of changes in order to lose weight and to keep that weight off over time. You will be healthier and your body will work more efficiently if you choose nutritious, high-quality foods and effective, high-impact exercises. Here are some steps to help you out.

The results you get from teeth whitening depend on what your teeth were like when you started. Some people think whitening erases all the damage they’ve done to their teeth over their lifetimes, but the opposite is true: The better you’ve cared for your teeth, the greater the results. The more you’ve maintained regular dental appointments, brushed and flossed regularly, and avoided damage and discoloration, the whiter your teeth will appear after a teeth whitening service.

The procedure can be broken down into several steps: Your doctor will choose one or more injection sites in the treatment areas and clean these areas with antiseptic. Your doctor will decide how much Restylane is needed. Your doctor will inject the Restylane under your skin into the treatment areas using an ultrafine needle. There are several kinds of Restylane that can be used for different areas of your face. This includes lips, cheeks, facial folds, and wrinkles. They’re all hyaluronic acid–based fillers, but each one was designed with a different specific purpose.

Fitness and alternative health news : Pilates puts minimal stress on your joints. Aging is a real thing and along with it comes arthritis. The key to combating arthritis is optimizing the area around the affected joint or joints. When you have good mobility, and balanced strength, you have less compressive forces around your joints. Arthritis doesn’t like compressed, crowded joints. So when you strengthen and stretch your whole body in a good, balanced way — arthritis becomes less painful and stiff. Pilates helps with all this and doesn’t cause any added stress on your joints. There’s a good reason you see lots of folks in their 60’s and 70’s enjoying our classes.

You may be surprised to discover that baking soda is a natural tooth whitener. It’s actually in most kinds of toothpaste! To use it directly on your teeth and whiten them mix a quarter of a teaspoon of baking soda with some water to make a paste. Then simply apply it to your teeth. You’ll need to do this every day to see the effects, it’s a gradual process. This is great for your teeth and your gums. Simply add a teaspoon of salt to a cup of boiled water and let it cool. You can then use it in the same way as you would a mouthwash. The salt is a natural antibacterial, killing unfriendly bacteria in your mouth.

Even though diet soda is typically non-caloric, it can still have a serious effect on your weight and overall health. Research published in 2015 in the Journal of the American Geriatrics Society found that diet soda consumption is associated with increased waist circumference and abdominal fat. “It’s vital to take photos and measurements and keep a training diary that details not just moves you do and weights you lift, but also how the session felt,” says personal trainer and fitness model Olly Foster. “This will give you the insight to make smart changes to your programme to keep your body guessing so the fat keeps falling off.” “Writing down what you eat is a great way of tracking your eating habits,” says personal trainer Adam Jones. “Does your nutrition differ on weekends or under times of stress? To go one step further, you could do this with a training partner and show each other what you’re eating. No one wants to write down McDonald’s or Krispy Kremes if they’re in friendly competition.” Discover more information on https://mytrendingstories.com/

Do you wish to maintain healthy teeth and gums? Here are some tricks: Avoid using your teeth for anything other than chewing food. If you use them to crack nuts, remove bottle tops or rip open packaging, you risk chipping or even breaking your teeth. See your dentist for regular check-ups. You should also visit your dentist if you have a dental problem such as a toothache or bleeding gums.

The cause: Not to be confused with cirrhosis (liver damage), this condition affects about 1 to 2% of the general population and anyone can get it, at any age. It’s thought to be an autoimmune condition in which the cells in the top layer of skin are in overdrive, manifesting as a pink rash with a characteristic silvery scale. Psoriasis can affect any part of the body from head to toe (including your nails), but the scalp kind is one of the most difficult types to treat, according to Seemal Desai, M.D., F.A.A.D., clinical assistant professor in the Department of Dermatology at the University of Texas Southwestern Medical Center. Why? The buildup of skin cells creates scaly, patches that can itch, hurt, crust up and bleed. Even more terrible: Trauma to the scalp (this means blow-drying and covering grays) can make the situation worse.